tooluniverse-cancer-variant-interpretation

Comprehensive clinical interpretation of somatic mutations in cancer. Transforms a gene + variant input into an actionable precision oncology report covering clinical evidence, therapeutic options, resistance mechanisms, clinical trials, and prognostic implications.

Required: Gene symbol + variant notation Optional: Cancer type (improves specificity)

| Gene + amino acid change | EGFR L858R | gene=EGFR, variant=L858R | | Gene + HGVS protein | BRAF p.V600E | gene=BRAF, variant=V600E | | Gene + exon notation | EGFR exon 19 deletion | gene=EGFR, variant=exon 19 deletion | | Gene + fusion | EML4-ALK fusion | gene=ALK, variant=EML4-ALK |

提供癌症体细胞突变的全面临床解释。给定基因符号 + 变异（例如 EGFR L858R、BRAF V600E）和可选的癌症类型，执行多数据库分析，涵盖临床证据 (CIViC)、突变流行率 (cBioPortal)、治疗关联（OpenTargets、ChEMBL、FDA）、耐药机制、临床试验、预后影响和途径背景。生成证据分级的降价报告，其中包含精准肿瘤学的可行建议。 Use when oncologists, molecular tumor boards, or researchers ask about treatment options for specific cancer mutations, resistance mechanisms, or clinical trial matching. 来源：mims-harvard/tooluniverse。