ligandmpnn
✓Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For solubility optimization, use solublempnn.
Installation
SKILL.md
| Python | 3.8+ | 3.10 | | CUDA | 11.0+ | 11.7+ | | GPU VRAM | 8GB | 16GB (T4) | | RAM | 8GB | 16GB |
First time? See Installation Guide to set up Modal and biomodals.
| --pdbpath | required | path | PDB with ligand | | --numseqpertarget | 1 | 1-1000 | Sequences per structure | | --samplingtemp | "0.1" | "0.0001-1.0" | Temperature (string!) | | --ligandmpnnusesidechaincontext | true | bool | Use ligand context |
Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For solubility optimization, use solublempnn. Source: adaptyvbio/protein-design-skills.
Facts (cite-ready)
Stable fields and commands for AI/search citations.
- Install command
npx skills add https://github.com/adaptyvbio/protein-design-skills --skill ligandmpnn- Category
- </>Dev Tools
- Verified
- ✓
- First Seen
- 2026-02-01
- Updated
- 2026-02-18
Quick answers
What is ligandmpnn?
Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For solubility optimization, use solublempnn. Source: adaptyvbio/protein-design-skills.
How do I install ligandmpnn?
Open your terminal or command line tool (Terminal, iTerm, Windows Terminal, etc.) Copy and run this command: npx skills add https://github.com/adaptyvbio/protein-design-skills --skill ligandmpnn Once installed, the skill will be automatically configured in your AI coding environment and ready to use in Claude Code or Cursor
Where is the source repository?
https://github.com/adaptyvbio/protein-design-skills
Details
- Category
- </>Dev Tools
- Source
- skills.sh
- First Seen
- 2026-02-01