tooluniverse-binder-discovery

SKILL.md

Systematic discovery of novel small molecule binders using 60+ ToolUniverse tools across druggability assessment, known ligand mining, similarity expansion, ADMET filtering, and synthesis feasibility.

DO NOT show search process or tool outputs to the user. Instead:

| OpenTargetsgettargettractabilitybyensemblID | ensemblid | ensemblId | | ChEMBLgettargetactivities | chembltargetid | targetchemblid | | ChEMBLsearchsimilarmolecules | smiles | molecule (accepts SMILES, ChEMBL ID, or name) | | alphafoldgetprediction | uniprot | accession |

Discover novel small molecule binders for protein targets using structure-based and ligand-based approaches. Creates actionable reports with candidate compounds, ADMET profiles, and synthesis feasibility. Use when users ask to find small molecules for a target, identify novel binders, perform virtual screening, or need hit-to-lead compound identification. Source: mims-harvard/tooluniverse.

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