ESM2 protein language model for embeddings and sequence scoring. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) scores, (2) Getting protein embeddings for clustering, (3) Filtering designs by sequence plausibility, (4) Zero-shot variant effect prediction, (5) Analyzing sequence-function relationships. For structure prediction, use chai or boltz. For QC thresholds, use protein-qc.
Installation
SKILL.md
| Python | 3.8+ | 3.10 | | PyTorch | 1.10+ | 2.0+ | | CUDA | 11.0+ | 11.7+ | | GPU VRAM | 8GB | 24GB (A10G) | | RAM | 16GB | 32GB |
First time? See Installation Guide to set up Modal and biomodals.
| esm2t68M | 8M | Fastest | Fast screening | | esm2t1235M | 35M | Fast | Good | | esm2t33650M | 650M | Medium | Better | | esm2t363B | 3B | Slow | Best |
ESM2 protein language model for embeddings and sequence scoring. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) scores, (2) Getting protein embeddings for clustering, (3) Filtering designs by sequence plausibility, (4) Zero-shot variant effect prediction, (5) Analyzing sequence-function relationships. For structure prediction, use chai or boltz. For QC thresholds, use protein-qc. Source: adaptyvbio/protein-design-skills.
Facts (cite-ready)
Stable fields and commands for AI/search citations.
- Install command
npx skills add https://github.com/adaptyvbio/protein-design-skills --skill esm- Category
- </>Dev Tools
- Verified
- ✓
- First Seen
- 2026-02-01
- Updated
- 2026-02-18
Quick answers
What is esm?
ESM2 protein language model for embeddings and sequence scoring. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) scores, (2) Getting protein embeddings for clustering, (3) Filtering designs by sequence plausibility, (4) Zero-shot variant effect prediction, (5) Analyzing sequence-function relationships. For structure prediction, use chai or boltz. For QC thresholds, use protein-qc. Source: adaptyvbio/protein-design-skills.
How do I install esm?
Open your terminal or command line tool (Terminal, iTerm, Windows Terminal, etc.) Copy and run this command: npx skills add https://github.com/adaptyvbio/protein-design-skills --skill esm Once installed, the skill will be automatically configured in your AI coding environment and ready to use in Claude Code or Cursor
Where is the source repository?
https://github.com/adaptyvbio/protein-design-skills
Details
- Category
- </>Dev Tools
- Source
- skills.sh
- First Seen
- 2026-02-01