fmri glm analysis guide

The General Linear Model (GLM) is the standard statistical framework for task-based fMRI analysis. It models the observed BOLD time series as a linear combination of expected signal components (task regressors convolved with the hemodynamic response function) plus confound regressors plus noise (Poline & Brett, 2012; Poldrack et al., 2011, Ch. 4).

This skill encodes the domain-specific judgment needed to correctly specify a GLM for fMRI data. A competent programmer without neuroimaging training would get many of these decisions wrong -- choosing the wrong HRF model, setting an inappropriate high-pass filter cutoff, omitting critical confound regressors, or applying invalid statistical thresholds. Each decision described here requires understanding the bioph...

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